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- Chairman, Retired, Roche Holding Ltd – 2008 to March 2014
- Chairman & Chief Executive Officer, Roche Group – 2001 to 2008
- Chief Executive Officer, Roche Group – 1998 to 2001
- Chief Operating Officer, F. Hoffmann-La Roche Ltd – 1996 to 1998
- Head of Pharmaceuticals, F. Hoffmann-La Roche Ltd – 1995 to 1996
- Director of Citigroup since 2012
- Other Directorship: Diageo plc (Chairman) and Kite Pharmaceuticals
- Previous Directorships within the last five years: Allianz SE and Roche Holdings Inc.
- Other Activities: International Centre for Missing and Exploited Children (Chairman), Humer Foundation, Bial Pharmaceuticals, Chugai Pharmaceuticals Ltd., and WISeKey (Member of the Board)